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In their trials, tirzepatide (Mounjaro) produced a higher average weight loss, about 20% of total body weight at the top dose, while orforglipron (Foundayo) produced about 12%, with some patients losing up to 15%

However, both medications require a titration period where the dose is slowly increased over several weeks to minimize side effects, so initial results are usually gradual for both

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The escalation schedule often follows this pattern: Week 1-4 : 0.25 mg once weekly Week 5-8 : 0.5 mg once weekly Week 9-12 : 1.0 mg once weekly Week 13-16 : 1.7 mg once weekly Week 17 and beyond : Up to 2.4 mg once weekly , which is the maximum dose for weight loss

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